Force High Resolution is dead simple to use program that's very effective (when it works).
Just select the programs that you want to run in VGA mode:
Here's Adobe Reader in QVGA mode, as you can see it's totally unreadable:
And here's the same page in VGA mode, now you can see the text perfectly - if you squint hard enough
The advantage of Force High Resolution over its competitors SE_VGA and ozVGA is that it is so easy to use. Just go into the system settings and run Force High Resolution, add the program you want to run in VGA mode then run selected program. There is no need to reset the machine. If a grumpy program doesn't like being run in VGA mode then simply remove it from the Force High Resolution list and the next time you run the grumpy program it will revert back to QVGA mode.
I must confess that I haven't actually tried SE_VGA (didn't like the idea of resetting my machine all the time) nor ozVGA (download link seems to be down)!